Last week was tricky for NFL game picks, but with few of the right upsets, we have added to the momentum of a hot start. But the degree of difficulty is getting raised in Week 4, with some smaller spreads for favorites and some true toss-up matchups.
We’ve also arrived at the first bye weeks. With the 49ers and Jets getting an early break, there are only 15 games on the schedule. The good news is that's one less chance to be wrong. The reality is it's one less chance to be right.
Regardless, let’s dive into our latest fearless forecast.
MORE: Get the latest NFL odds at Sportsbook Review
Week 4 NFL picks against the spread
Game of the Week: Dallas Cowboys (-2 1/2, -115) at New Orleans Saints
Sunday, 8:20 p.m. ET, NBC
The Cowboys matched up well against the Saints’ offense with Drew Brees last season because they don’t allow much deep, and they clean up against the run with their linebackers. They can squeeze easily on Teddy Bridgewater here. On the other side, Dak Prescott will keep finding matchups he loves in Dallas' explosive passing game. He has plenty of big road game juice on his resume and will ensure his team stays undefeated if the Saints focus on slowing down Ezekiel Elliott.
Cowboys win 27-20 and cover the spread.
Upset of the Week: Tennessee Titans over Atlanta Falcons (-4, -110)
Sunday, 1 p.m. ET, CBS
The Titans are a hard team to figure out. They dominated on the road, were mediocre at home and then got blown out on the road. They need to be able to stick with their run-heavy plan to support their edge-rushing 3-4 defense. This is that opportunity, as the Falcons can get gashed by Derrick Henry and, without Keanu Neal, will be challenged to stop Marcus Mariota’s go-to guy, tight end Delanie Walker. While Mariota gets all the support he needs to pull him out of a slump, the pressure is falling more on Matt Ryan. Tennessee will get after him and contain his wideouts downfield to save the game.
Titans win 20-17.
Lock of the Week: Los Angeles Rams (-10, +110) over Tampa Bay Buccaneers
Sunday, 4:05 p.m. ET, Fox
The Rams have shown no signs of a Super Bowl hangover, posting two tough road wins as part of their 3-0 start. Back home, they face a team traveling cross-country into an unfamiliar later kickoff. Sean McVay swept Bruce Arians’ Cardinals in dominant fashion two years ago. The Bucs can’t handle the Rams’ diverse receiving corps, and Jameis Winston can expect some discomfort from Aaron Donald as the deep-ball opportunities become limited.
Rams win 33-17 and cover the spread.
Carolina Panthers at Houston Texans (-5, -110)
Sunday, 1 p.m. ET, Fox
The Kyle Allen homecoming tour continues, going from his old high school stomping grounds back to wher